John Bishop - 01 Aug 2025 Form 3 Insider Report for ARDELYX, INC. (ARDX)

Role: Chief Technical Operations Officer Exhibit 24.1 - Power of Attorney
Signature: /s/ Elizabeth Grammer, Attorney-in-Fact for John Bishop
Issuer symbol: ARDX
Transactions as of: 01 Aug 2025
Net transactions value: $0
Form type: 3
Filing time: 17 Oct 2025, 18:18:13 UTC
Previous filing: 01 Feb 2024
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Bishop John E	Chief Technical Operations Officer Exhibit 24.1 - Power of Attorney	C/O ARDELYX, INC., 400 FIFTH AVENUE, SUITE 210, WALTHAM	/s/ Elizabeth Grammer, Attorney-in-Fact for John Bishop	17 Oct 2025	0001308911

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	ARDX	Common Stock						218,000	01 Aug 2025	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
holding	ARDX	Stock Option (Right to Buy)							01 Aug 2025	Common Stock	327,000	$4.49	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Restricted stock units ("RSUs"). The Reporting Person is entitled to receive one (1) shares of Common Stock for each one (1) RSU upon the vesting thereof.
F2	Twenty Five Percent (25%) of the shares subject to the option vest on July 14, 2026 and the remaining shares subject to the option vest in 36 successive, equal monthly installments thereafter, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date.

Remarks:

Chief Technical Operations Officer Exhibit 24.1 - Power of Attorney