Aquilo Capital Management, LLC - Apr 26, 2022 Form 4 Insider Report for Spero Therapeutics, Inc. (SPRO)

Role: 10%+ Owner
Signature: Aquilo Capital Management, LLC By: Marc Schneidman, its Managing Member, /s/ Marc Schneidman
Stock symbol: SPRO
Transactions as of: Apr 26, 2022
Transactions value $: $207,971
Form type: 4
Date filed: 4/28/2022, 04:13 PM
Previous filing: Mar 31, 2022
Next filing: Sep 26, 2022

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	SPRO	Common Stock, $0.001 par value	Purchase	$208K	+39.7K	+0.75%	$5.24	5.32M	Apr 26, 2022	See Footnotes	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.
F2	Aquilo Capital, LP only owns 3,511,982 of the 5,321,231 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP purchased 39,727 shares in this transaction on 4/26/2022.

Content

The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

Aquilo Capital, LP only owns 3,511,982 of the 5,321,231 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP purchased 39,727 shares in this transaction on 4/26/2022.