| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Almstead Neil Gregory | CHIEF TECHNICAL OPS OFFICER | C/O PTC THERAPEUTICS, INC., 500 WARREN CORPORATE CENTER DRIVE, WARREN | /s/ Avraham S. Adler, Attorney-in-Fact | 26 Nov 2025 | 0001578850 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PTCT | Common Stock | Options Exercise | $44,575 | +2,475 | +2.5% | $18.01 | 103,100 | 25 Nov 2025 | Direct | F1 |
| transaction | PTCT | Common Stock | Sale | $75,276 | -911 | -0.88% | $82.63 | 102,189 | 25 Nov 2025 | Direct | F1, F2 |
| transaction | PTCT | Common Stock | Sale | $82,606 | -990 | -0.97% | $83.44 | 101,199 | 25 Nov 2025 | Direct | F1, F3 |
| transaction | PTCT | Common Stock | Sale | $48,601 | -574 | -0.57% | $84.67 | 100,625 | 25 Nov 2025 | Direct | F1, F4 |
| transaction | PTCT | Common Stock | Options Exercise | $66,700 | +2,020 | +2% | $33.02 | 102,645 | 25 Nov 2025 | Direct | F1 |
| transaction | PTCT | Common Stock | Sale | $56,932 | -689 | -0.67% | $82.63 | 101,956 | 25 Nov 2025 | Direct | F1, F5 |
| transaction | PTCT | Common Stock | Sale | $71,848 | -862 | -0.85% | $83.35 | 101,094 | 25 Nov 2025 | Direct | F1, F6 |
| transaction | PTCT | Common Stock | Sale | $24,452 | -289 | -0.29% | $84.61 | 100,805 | 25 Nov 2025 | Direct | F1, F7 |
| transaction | PTCT | Common Stock | Sale | $15,331 | -180 | -0.18% | $85.17 | 100,625 | 25 Nov 2025 | Direct | F1, F8 |
| transaction | PTCT | Common Stock | Options Exercise | $151,464 | +8,410 | +8.4% | $18.01 | 109,035 | 25 Nov 2025 | Direct | F1 |
| transaction | PTCT | Common Stock | Sale | $231,068 | -2,790 | -2.6% | $82.82 | 106,245 | 25 Nov 2025 | Direct | F1, F9 |
| transaction | PTCT | Common Stock | Sale | $305,531 | -3,663 | -3.4% | $83.41 | 102,582 | 25 Nov 2025 | Direct | F1, F10 |
| transaction | PTCT | Common Stock | Sale | $148,572 | -1,757 | -1.7% | $84.56 | 100,825 | 25 Nov 2025 | Direct | F1, F11 |
| transaction | PTCT | Common Stock | Sale | $17,074 | -200 | -0.2% | $85.37 | 100,625 | 25 Nov 2025 | Direct | F1, F12 |
| transaction | PTCT | Common Stock | Options Exercise | $1,572,544 | +47,624 | +47% | $33.02 | 148,249 | 25 Nov 2025 | Direct | F1 |
| transaction | PTCT | Common Stock | Sale | $1,115,581 | -13,514 | -9.1% | $82.55 | 134,735 | 25 Nov 2025 | Direct | F1, F13 |
| transaction | PTCT | Common Stock | Sale | $1,820,261 | -21,844 | -16% | $83.33 | 112,891 | 25 Nov 2025 | Direct | F1, F14 |
| transaction | PTCT | Common Stock | Sale | $774,216 | -9,171 | -8.1% | $84.42 | 103,720 | 25 Nov 2025 | Direct | F1, F15 |
| transaction | PTCT | Common Stock | Sale | $263,539 | -3,095 | -3% | $85.15 | 100,625 | 25 Nov 2025 | Direct | F1, F16 |
| transaction | PTCT | Common Stock | Options Exercise | $376,395 | +11,399 | +11% | $33.02 | 112,024 | 25 Nov 2025 | Direct | F1 |
| transaction | PTCT | Common Stock | Sale | $309,292 | -3,744 | -3.3% | $82.61 | 108,280 | 25 Nov 2025 | Direct | F1, F17 |
| transaction | PTCT | Common Stock | Sale | $403,107 | -4,834 | -4.5% | $83.39 | 103,446 | 25 Nov 2025 | Direct | F1, F18 |
| transaction | PTCT | Common Stock | Sale | $221,579 | -2,621 | -2.5% | $84.54 | 100,825 | 25 Nov 2025 | Direct | F1, F19 |
| transaction | PTCT | Common Stock | Sale | $17,068 | -200 | -0.2% | $85.34 | 100,625 | 25 Nov 2025 | Direct | F1, F20 |
| holding | PTCT | Common Stock | 6,179 | 25 Nov 2025 | By Spouse |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PTCT | Stock Option (Right to Buy) | Options Exercise | $0 | -2,475 | -23% | $0.000000 | 8,410 | 25 Nov 2025 | Common Stock | 2,475 | $18.01 | Direct | F1, F21 |
| transaction | PTCT | Stock Option (Right to Buy) | Options Exercise | $0 | -2,020 | -4.1% | $0.000000 | 47,624 | 25 Nov 2025 | Common Stock | 2,020 | $33.02 | Direct | F1, F21 |
| transaction | PTCT | Stock Option (Right to Buy) | Options Exercise | $0 | -8,410 | -100% | $0.000000 | 0 | 25 Nov 2025 | Common Stock | 8,410 | $18.01 | Direct | F1, F21 |
| transaction | PTCT | Stock Option (Right to Buy) | Options Exercise | $0 | -47,624 | -100% | $0.000000 | 0 | 25 Nov 2025 | Common Stock | 47,624 | $33.02 | Direct | F1, F21 |
| transaction | PTCT | Stock Option (Right to Buy) | Options Exercise | $0 | -11,399 | -100% | $0.000000 | 0 | 25 Nov 2025 | Common Stock | 11,399 | $33.02 | Direct | F1, F21 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 10, 2024. |
| F2 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F3 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.96 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F4 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F5 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F6 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.96 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F7 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F8 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.16 to $85.17 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F9 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.99 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F10 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F11 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.83 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F12 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.33 to $85.41 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F13 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $81.85 to $82.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F14 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.95 to $83.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F15 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.95 to $84.92 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F16 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.37 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F17 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.99 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F18 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F19 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F20 | This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.33 to $85.34 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. |
| F21 | Currently exercisable. |