| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| ABG Management Ltd. | 10%+ Owner | #3902, 39/F, E TOWER, 10 HARCOURT RD CTR, HONG KONG, HONG KONG | ABG Management Ltd., By: /s/ Fan Yu, Director | 05 Feb 2026 | 0001832106 |
| Ally Bridge MedAlpha Master Fund L.P. | 10%+ Owner | C/O MAPLES CORPORATE SERVICES LIMITED,, P.O. BOX 309, UGLAND HOUSE,, GRAND CAYMAN,, CAYMAN ISLANDS | Ally Bridge MedAlpha Master Fund L.P., By: Ally Bridge Group (NY) LLC, its manager, By: ABG Management Ltd., its managing member, By: /s/ Fan Yu, Director | 05 Feb 2026 | 0001831963 |
| Ally Bridge Group (NY) LLC | 10%+ Owner | 430 PARK AVENUE, 12TH FLOOR, NEW YORK, | Ally Bridge Group (NY) LLC, By: ABG Management Ltd., its managing member, By: /s/ Fan Yu, Director | 05 Feb 2026 | 0001822947 |
| Yu Fan | 10%+ Owner | #3902, 39/F, E TOWER,, 10 HARCOURT RD CTR, HONG KONG, HONG KONG | /s/ Fan Yu | 05 Feb 2026 | 0001668029 |
| Alex Slanix Paul | Director | C/O PROMIS NEUROSCIENCES INC., SUITE 200, 1920 YONGE STREET, TORONTO,, ONTARIO, CANADA | /s/ Michael Bendetson, Attorney-in-Fact for Slanix Alex | 05 Feb 2026 | 0002092283 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PMN | Common Shares | Purchase | $8,499,988 | +700,741 | +289% | $12.13 | 943,090 | 03 Feb 2026 | See Footnote | F1, F2, F3, F4, F5 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PMN | Warrants | Purchase | +700,741 | 700,741 | 03 Feb 2026 | Common Shares | 700,741 | $14.40 | See Footnote | F1, F3, F4, F5, F6, F7 |
| Id | Content |
|---|---|
| F1 | The Warrants were purchased together with the Common Shares reported herein for an aggregate purchase price of $12.13 per Common Share. |
| F2 | The Common Shares reported herein include: (i) 407,230 Common Shares held of record by Ally Bridge MedAlpha Master Fund L.P., (ii) 329,760 Common Shares held of record by ABG V-SIV IX Limited and (iii) 206,100 Common Shares held of record by ABG V-SIV X Limited. |
| F3 | Mr. Fan Yu is the controlling stockholder of ABG Management Ltd., which is the sole member of Ally Bridge Group (NY) LLC, which manages the investments of Ally Bridge MedAlpha Master Fund L.P. As such, each of the foregoing entities and Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by Ally Bridge MedAlpha Master Fund L.P. |
| F4 | Mr. Fan Yu is also the indirect controlling stockholder of ABG Global Life Science Capital Partners V GP Limited, which is the general partner of ABG Global Life Science Capital Partners V GP, L.P., which is the general partner of Ally Bridge Group Global Life Science Capital Partners V, L.P., which is the controlling shareholder of ABG V-SIV IX Limited. As such, each of the foregoing entities and Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by ABG V-SIV IX Limited. |
| F5 | Mr. Fan Yu is also the controlling stockholder of ABG V-SIV X Limited. As such, Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by ABG V-SIV X Limited. |
| F6 | The warrants to purchase Common Shares (the "Warrants") are exercisable immediately and will expire upon the earlier of (i) within 60 days of the Milestone Event or (ii) February 3, 2031. For purposes of the foregoing, the "Milestone Event" means the public announcement via press release or the filing of a Current Report on Form 8-K by the Issuer of topline data from the cohorts treated with single ascending doses of PMN310. |
| F7 | The Warrants reported herein include: (i) Warrants to purchase 164,881 Common Shares held of record by Ally Bridge MedAlpha Master Fund L.P., (ii) Warrants to purchase 329,760 Common Shares held of record by ABG V-SIV IX Limited and (iii) Warrants to purchase 206,100 Common Shares held of record by ABG V-SIV X Limited. |
Each of ABG Global Life Science Capital Partners V GP Limited, ABG Global Life Science Capital Partners V GP, L.P., Ally Bridge Group Global Life Science Capital Partners V, L.P., ABG V-SIV IX Limited and ABG V-SIV X Limited will file a Form 3 in connection with the transactions reported herein and thereafter are expected to file Forms 4 jointly with the reporting persons.