Guy Warren Primus - 24 Dec 2025 Form 4 Insider Report for LIXTE BIOTECHNOLOGY HOLDINGS, INC. (LIXT)

Role: Director
Signature: /s/ Guy Primus
Issuer symbol: LIXT
Transactions as of: 24 Dec 2025
Net transactions value: $0
Form type: 4
Filing time: 29 Dec 2025, 19:19:14 UTC
Previous filing: 10 Sep 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Primus Guy Warren	Director	680 E. COLORADO BOULEVARD,, SUITE 180, PASADENA	/s/ Guy Primus	29 Dec 2025	0002085122

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	LIXT	Stock Option (right to buy)	Award	$0	+25,000		$0.000000	25,000	24 Dec 2025	Common Stock	25,000	$4.05	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Fifty percent (50%) of the option vested and became exercisable on the grant date. The remaining fifty percent (50%) vests in equal installments of twelve and one-half percent (12.5%) on March 31, 2026 and on the last date of each subsequent calendar quarter thereafter until fully vested, subject to the reporting person's continuous service through each applicable vesting date.