Krishnan Viswanadhan - 05 Mar 2026 Form 4 Insider Report for AGIOS PHARMACEUTICALS, INC. (AGIO)

Role: Chief Corp Dev & Strategy
Signature: /s/ William Cook, as Attorney in Fact for Krishnan Viswanadhan
Issuer symbol: AGIO
Transactions as of: 05 Mar 2026
Net transactions value: -$82,260
Form type: 4
Filing time: 09 Mar 2026, 16:12:11 UTC
Previous filing: 03 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Viswanadhan Krishnan	Chief Corp Dev & Strategy	88 SIDNEY STREET, CAMBRIDGE	/s/ William Cook, as Attorney in Fact for Krishnan Viswanadhan	09 Mar 2026	0001999913

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	AGIO	Common stock	Options Exercise		+8,100		$0.000000^*	8,100	05 Mar 2026	Direct
transaction	AGIO	Common stock	Sale	$82,260	-2,959	-37%	$27.80	5,141	05 Mar 2026	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	AGIO	Restricted stock units	Options Exercise		-8,100	-33%	$0.000000^*	16,200	05 Mar 2026	Common stock	8,100		Direct	F2, F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id	Content
F1	Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 5, 2025.
F2	Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.
F3	The restricted stock units were granted on March 5, 2025. Beginning on March 5, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.