| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| ALAM JOHN J | CEO & President, Director, 10%+ Owner | 20 PARK PLAZA, SUITE 424, BOSTON | /s/ William R. Elder, attorney-in-fact for the Reporting Person | 13 Nov 2025 | 0001197014 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | CRVO | Common Stock | Purchase | $40,815 | +5,553 | +0.38% | $7.35 | 1,467,131 | 12 Nov 2025 | Direct | F1, F2 |
| Id | Content |
|---|---|
| F1 | Shares purchased in open-market transactions. |
| F2 | Shares held jointly by the Reporting Person and his spouse, Dr. Sylvie Gregoire, PharmD., a member of the Issuer's Board of Directors. |