DAVID J. MATLIN - 14 Aug 2025 Form 4 Insider Report for Clene Inc. (CLNN)

Role: Director
Signature: /s/ Jerome T. Miraglia POA
Issuer symbol: CLNN
Transactions as of: 14 Aug 2025
Transactions value $: $0
Form type: 4
Filing time: 15 Aug 2025, 09:12:43 UTC
Previous filing: 27 Jun 2025
Next filing: 14 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
MATLIN DAVID J	Director	6550 SOUTH MILLROCK DRIVE, SUITE G50, SALT LAKE CITY	/s/ Jerome T. Miraglia POA	15 Aug 2025	0001251956

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	CLNN	stock option	Award	$0	+7.26K		$0.00	7.26K	14 Aug 2025	common stock	7.26K	$3.60	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This option was granted on August 14, 2025 as an option for 7,255 share of Common Stock under the Clene Inc. Amended 2020 Stock Plan at an exercise price of $3.60 per share. The options vest immediately upon grant.