| Id | Content |
|---|---|
| F1 | Reflects a grant of restricted shares, which will vest and become non-forfeitable based on the Company's total shareholder return relative to the Nasdaq Biotechnology Index over a one-year to five-year period, provided that the Reporting Person remains an employee, director and/or consultant of the Company through each vesting date. |
| F2 | Includes shares of restricted Common Stock, which vest over various time periods. |