Sukumar Nagendran - Sep 10, 2025 Form 4 Insider Report for Taysha Gene Therapies, Inc. (TSHA)

Signature
/s/ Kamran Alam, Attorney-in-Fact
Stock symbol
TSHA
Transactions as of
Sep 10, 2025
Transactions value $
-$617,240
Form type
4
Date filed
9/12/2025, 04:15 PM
Previous filing
Aug 22, 2025
Next filing
Dec 1, 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Nagendran Sukumar President and Head of R&D, Director C/O TAYSHA GENE THERAPIES, INC., 3000 PEGASUS PARK DRIVE, SUITE 1430, DALLAS /s/ Kamran Alam, Attorney-in-Fact 2025-09-12 0001665124

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction TSHA Common Stock Options Exercise $28.8K +41.2K +3.53% $0.70 1.21M Sep 10, 2025 Direct
transaction TSHA Common Stock Sale -$646K -200K -16.58% $3.23 1.01M Sep 10, 2025 Direct F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction TSHA Employee Stock Option (right to buy) Options Exercise $0 -41.2K -12.32% $0.00 293K Sep 10, 2025 Common Stock 41.2K $0.70 Direct F3
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 11, 2025.
F2 The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.165 to $3.31 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
F3 The shares underlying the option vested or shall vest and become exercisable in three equal annual installments commencing on December 31, 2024, subject to the Reporting Person's continuous service through each applicable vesting date.