RTW INVESTMENTS, LP - 04 Aug 2025 Form 4 Insider Report for Orchestra BioMed Holdings, Inc. (OBIO)

Role: 10%+ Owner
Signature: /s/ Roderick Wong, for RTW Investments, LP, By: Roderick Wong, M.D., Managing Partner
Issuer symbol: OBIO
Transactions as of: 04 Aug 2025
Net transactions value: +$9,999,635
Form type: 4
Filing time: 06 Aug 2025, 16:28:01 UTC
Previous filing: 01 May 2025
Next filing: 23 Sep 2025
SEC: View on sec.gov

Reporting Owners (2)

Name	Relationship	Address	Signature	Signature date	CIK
RTW INVESTMENTS, LP	10%+ Owner	40 10TH AVENUE, FLOOR 7, NEW YORK	/s/ Roderick Wong, for RTW Investments, LP, By: Roderick Wong, M.D., Managing Partner	06 Aug 2025	0001493215
WONG RODERICK	10%+ Owner	40 10TH AVENUE, FLOOR 7, NEW YORK	/s/ Roderick Wong, By: Roderick Wong, M.D.	06 Aug 2025	0001493280

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	OBIO	Pre-Funded Warrants (Right to Buy)	Purchase	$9,999,635	+3,636,363		$2.75	3,636,363	04 Aug 2025	Common Stock	3,636,363	$0.000100	See footnote	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The Pre-Funded Warrants have no expiration date and are exercisable immediately. Notwithstanding the foregoing, the Reporting Persons shall not be entitled to exercise the Pre-Funded Warrants to the extent that it would cause the aggregate number of shares of Common Stock beneficially owned by the Reporting Persons, together with their Attribution Parties (as defined in the Pre-Funded Warrants), to exceed 9.99% of the total number of issued and outstanding shares of Common Stock of the Issuer following such exercise.
F2	Held by certain affiliated funds managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The Reporting Persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein.

Content

The Pre-Funded Warrants have no expiration date and are exercisable immediately. Notwithstanding the foregoing, the Reporting Persons shall not be entitled to exercise the Pre-Funded Warrants to the extent that it would cause the aggregate number of shares of Common Stock beneficially owned by the Reporting Persons, together with their Attribution Parties (as defined in the Pre-Funded Warrants), to exceed 9.99% of the total number of issued and outstanding shares of Common Stock of the Issuer following such exercise.

Held by certain affiliated funds managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The Reporting Persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein.