Christina Rossi - 03 Jul 2025 Form 4 Insider Report for Blueprint Medicines Corp (BPMC)

Role: CHIEF OPERATING OFFICER
Signature: /s/ Melissa Masse, Attorney-in-Fact
Issuer symbol: BPMC
Transactions as of: 03 Jul 2025
Net transactions value: -$150,309
Form type: 4
Filing time: 08 Jul 2025, 16:20:07 UTC
Previous filing: 12 Jun 2025
Next filing: 21 Jul 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Rossi Christina	CHIEF OPERATING OFFICER	C/O BLUEPRINT MEDICINES CORPORATION, 45 SIDNEY STREET, CAMBRIDGE	/s/ Melissa Masse, Attorney-in-Fact	08 Jul 2025	0001756941

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	BPMC	Common Stock	Sale	$150,309	-1,172	-1.8%	$128.25	63,546	03 Jul 2025	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.