| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Krishnan Krish S | President and CEO, Director, 10%+ Owner | C/O KRYSTAL BIOTECH, INC., 2100 WHARTON STREET, SUITE 701, PITTSBURGH | /s/ Krish S. Krishnan | 03 Mar 2026 | 0001298709 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | KRYS | Common Stock | Options Exercise | $0 | +8,750 | +0.59% | $0.000000 | 1,486,806 | 27 Feb 2026 | Direct | F1 |
| transaction | KRYS | Common Stock | Tax liability | $1,097,323 | -3,981 | -0.27% | $275.64 | 1,482,825 | 27 Feb 2026 | Direct | F2, F3 |
| transaction | KRYS | Common Stock | Options Exercise | $0 | +26,250 | +1.8% | $0.000000 | 1,509,075 | 27 Feb 2026 | Direct | F4 |
| transaction | KRYS | Common Stock | Tax liability | $3,291,693 | -11,942 | -0.79% | $275.64 | 1,497,133 | 27 Feb 2026 | Direct | F3, F5 |
| transaction | KRYS | Common Stock | Options Exercise | $0 | +5,725 | +0.38% | $0.000000 | 1,502,858 | 27 Feb 2026 | Direct | F6 |
| transaction | KRYS | Common Stock | Tax liability | $718,042 | -2,605 | -0.17% | $275.64 | 1,500,253 | 27 Feb 2026 | Direct | F3, F7 |
| transaction | KRYS | Common Stock | Options Exercise | $0 | +22,500 | +1.6% | $0.000000 | 1,436,211 | 27 Feb 2026 | By Spouse | F8, F9, F10 |
| transaction | KRYS | Common Stock | Tax liability | $2,821,451 | -10,236 | -0.71% | $275.64 | 1,425,975 | 27 Feb 2026 | By Spouse | F3, F9, F10, F11 |
| transaction | KRYS | Common Stock | Options Exercise | $0 | +4,000 | +0.28% | $0.000000 | 1,429,975 | 27 Feb 2026 | By Spouse | F9, F10, F12 |
| transaction | KRYS | Common Stock | Tax liability | $501,665 | -1,820 | -0.13% | $275.64 | 1,428,155 | 27 Feb 2026 | By Spouse | F3, F9, F10, F13 |
| holding | KRYS | Common Stock | 90,000 | 27 Feb 2026 | By Krishnan Spousal Trust | ||||||
| holding | KRYS | Common Stock | 50,000 | 27 Feb 2026 | By Krishnan Family Trust | F14 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | KRYS | Restricted Stock Units | Options Exercise | $0 | -8,750 | -33% | $0.000000 | 17,500 | 27 Feb 2026 | Common Stock | 8,750 | Direct | F1 | |
| transaction | KRYS | Performance Stock Units | Options Exercise | $0 | -26,250 | -100% | $0.000000 | 0 | 27 Feb 2026 | Common Stock | 26,250 | Direct | F4 | |
| transaction | KRYS | Restricted Stock Units | Options Exercise | $0 | -5,725 | -25% | $0.000000 | 17,175 | 27 Feb 2026 | Common Stock | 5,725 | Direct | F6 | |
| transaction | KRYS | Stock Option (Right to Buy) | Award | $0 | +45,249 | $0.000000 | 45,249 | 27 Feb 2026 | Common Stock | 45,249 | $275.64 | Direct | F15 | |
| transaction | KRYS | Restricted Stock Units | Award | $0 | +18,140 | $0.000000 | 18,140 | 27 Feb 2026 | Common Stock | 18,140 | Direct | F16, F17, F18 |
| Id | Content |
|---|---|
| F1 | 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period. 8,750 RSUs vested on February 27, 2026. |
| F2 | Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 8,750 RSUs on February 27, 2026. |
| F3 | The closing price on February 27, 2026 of the Company's common stock on the Nasdaq Global Select Market. |
| F4 | 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 26,250 PSUs, vested on February 27, 2026. |
| F5 | Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 26,250 PSUs on February 27, 2026. |
| F6 | 22,900 restricted stock units ("RSUs") were granted on February 28, 2025. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 5,725 RSUs, vesting on February 27, 2026. |
| F7 | Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 5,725 RSUs on February 27, 2026. |
| F8 | 45,000 performance stock units ("PSUs") were granted on February 29, 2024, to the Reporting Person's spouse, Suma M. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 22,500 PSUs, vested on February 27, 2026. |
| F9 | These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan. |
| F10 | Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person. |
| F11 | Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 22,500 PSUs on February 27, 2026. |
| F12 | 16,000 restricted stock units ("RSUs") were granted on February 28, 2025 to the Reporting Person's spouse, Suma M. Krishnan. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 4,000 RSUs, vesting on February 27, 2026. |
| F13 | Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 4,000 RSUs on February 27, 2026. |
| F14 | Directly beneficially owned by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control. |
| F15 | The stock options vests in four equal annual installments beginning on February 27, 2027. |
| F16 | Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. |
| F17 | The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates. |
| F18 | The RSUs vest in four equal annual installments with the first installment vesting on February 27, 2027. |