RA CAPITAL MANAGEMENT, L.P. - 08 Dec 2025 Form 4 Insider Report for Fulcrum Therapeutics, Inc. (FULC)

Role
10%+ Owner
Signature
/s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.
Issuer symbol
FULC
Transactions as of
08 Dec 2025
Net transactions value
-$58,377,021
Form type
4
Filing time
10 Dec 2025, 16:42:29 UTC
Previous filing
24 Nov 2025
Next filing
15 Dec 2025

Reporting Owners (4)

Name Relationship Address Signature Signature date CIK
RA CAPITAL MANAGEMENT, L.P. 10%+ Owner 200 BERKELEY STREET, 18TH FLOOR, BOSTON /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P. 10 Dec 2025 0001346824
RA Capital Healthcare Fund LP 10%+ Owner 200 BERKELEY STREET, 18TH FLOOR, BOSTON /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P. 10 Dec 2025 0001315082
Kolchinsky Peter 10%+ Owner C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON /s/ /s/ Peter Kolchinsky, individually 10 Dec 2025 0001384859
Shah Rajeev M. 10%+ Owner C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON /s/ Rajeev Shah, individually 10 Dec 2025 0001619841

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction FULC Common Stock Sale $18,355,677 -1,377,020 -13% $13.33 8,852,079 08 Dec 2025 See footnotes F1, F2, F3
transaction FULC Common Stock Sale $38,647,349 -2,706,397 -31% $14.28 6,145,682 08 Dec 2025 See footnotes F2, F3, F4
transaction FULC Common Stock Sale $1,373,996 -91,722 -1.5% $14.98 6,053,960 08 Dec 2025 See footnotes F2, F3, F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.81 to $13.8099 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
F2 RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund. The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.
F3 Held directly by the Fund.
F4 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.81 to $14.805 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
F5 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.81 to $15.39 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.