Andrew Guggenhime - 26 Feb 2026 Form 4 Insider Report for Vaxcyte, Inc. (PCVX)

Role: PRESIDENT AND CFO
Signature: Andrew Guggenhime, by /s/ Peter N. Efremenko, Attorney-In-Fact
Issuer symbol: PCVX
Transactions as of: 26 Feb 2026
Net transactions value: -$118,196
Form type: 4
Filing time: 02 Mar 2026, 20:08:11 UTC
Previous filing: 20 Feb 2026
Next filing: 11 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
GUGGENHIME ANDREW	PRESIDENT AND CFO	C/O VAXCYTE, INC., 825 INDUSTRIAL ROAD, STE. 300, SAN CARLOS	Andrew Guggenhime, by /s/ Peter N. Efremenko, Attorney-In-Fact	02 Mar 2026	0001230724

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	PCVX	Common Stock	Award	$0	+44,864	+72%	$0.000000	107,323	26 Feb 2026	Direct	F1
transaction	PCVX	Common Stock	Tax liability	$55,658	-898	-0.84%	$61.98	106,425	28 Feb 2026	Direct	F2
transaction	PCVX	Common Stock	Tax liability	$62,538	-1,009	-0.95%	$61.98	105,416	02 Mar 2026	Direct	F2
holding	PCVX	Common Stock						61,850	26 Feb 2026	See Footnote	F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PCVX	Stock Option (right to buy)	Award	$0	+74,993		$0.000000	74,993	26 Feb 2026	Common Stock	74,993	$60.00	Direct	F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents the number of shares of Common Stock underlying restricted stock units ("RSUs"). Each RSU represents the contingent right to receive one share of the Issuer's Common Stock. The RSUs vest as to 1/4 of the shares subject to the award on September 7, 2026 and 1/8 of the shares every six months thereafter, subject to Reporting Person's continuous service with the Issuer through each such date.
F2	Represents shares surrendered to the Issuer to cover applicable tax withholding obligations realized upon the vesting of RSUs.
F3	Shares are held by ALG 2025 GRAT HOLDINGS LLC, of which 100% of the limited liability company interest is owned by a grantor retained annuity trust, of which the Reporting Person is the annuitant and the trustee.
F4	1/48 of shares subject to the option vest on March 26, 2026, and 1/48 of the shares vest monthly thereafter, subject to Reporting Person's continuous service with the Issuer through each such date.