Yousha Neman-Ebrahim - 05 Jun 2025 Form 4 Insider Report for NEONC TECHNOLOGIES HOLDINGS, INC. (NTHI)

Role: Chief Clinical Officer
Signature: /s/ Yousha Neman-Ebrahim
Issuer symbol: NTHI
Transactions as of: 05 Jun 2025
Net transactions value: $0
Form type: 4
Filing time: 09 Jun 2025, 19:40:19 UTC
Next filing: 24 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Neman-Ebrahim Yousha	Chief Clinical Officer	23975 PARK SORRENTO, SUITE 205, CALABASAS	/s/ Yousha Neman-Ebrahim	09 Jun 2025	0002071642

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	NTHI	Common Stock	Award		+133,000			133,000	05 Jun 2025	Direct	F1, F2, F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	NTHI	Common Stock	Award		+67,000			67,000	05 Jun 2025	Common Stock	67,000		Direct	F3, F4, F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Shares of restricted common stock ("Restricted Stock") granted pursuant to Issuer's 2023 Equity Incentive Plan (the "Incentive Plan"). Pursuant to Reporting Person's Restricted Stock Award Agreement dated June 5, 2025 (the "Agreement"), Issuer granted a total of 200,000 shares of common stock to Reporting Person. Of such shares, (i) 66,000 shares vest seventh months from the date of grant, (ii) one-third, or approximately 67K shares, vest in 29 equal monthly installments thereafter, and (iii) the remaining one-third, or approximately 67K shares, are performance based with vesting predicated on achievement of certain performance metrics.
F2	See footnote 1.
F3	Not applicable.
F4	Restricted common stock granted pursuant to Issuer's Incentive Plan. Vesting and exercise of such shares are based on achievement of certain performance metrics. See also footnote 1.
F5	This is a target number only. The actual number of shares of common stock deliverable is subject to adjustment as described in the Agreement. Reporting Person may acquire shares of Issuer's common stock to the extent that the performance metrics have been achieved. See also footnote 1.