David Roth - Oct 31, 2023 Form 4 Insider Report for Syros Pharmaceuticals, Inc. (SYRS)

Role: Chief Medical Officer
Signature: /s/ Todd Rosenthal, as attorney-in-fact
Stock symbol: SYRS
Transactions as of: Oct 31, 2023
Transactions value $: -$13,988
Form type: 4
Date filed: 11/2/2023, 04:52 PM
Previous filing: Aug 2, 2023
Next filing: Dec 8, 2023

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	SYRS	Common Stock	Options Exercise		+18.9K			18.9K	Oct 31, 2023	Direct	F1
transaction	SYRS	Common Stock	Tax liability	-$14K	-6.3K	-33.38%	$2.22	12.6K	Nov 1, 2023	Direct	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SYRS	Restricted Stock Units	Options Exercise	$0	-18.9K	-50%	$0.00	18.9K	Oct 31, 2023	Common Stock	18.9K		Direct	F3, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents shares of common stock received upon vesting of a restricted stock unit award.
F2	Represents shares used to cover tax withholding on a restricted stock unit release.
F3	Each restricted stock unit represents the contingent right to receive one share of the issuer's common stock.
F4	Represents a restricted stock unit award granted on October 6, 2022. These restricted stock units vested as to one half (50%) of the shares on October 31, 2023, and are scheduled to vest as to one half (50%) of the shares on October 31, 2024.