Paul B. Manning - Aug 16, 2023 Form 4 Insider Report for Taysha Gene Therapies, Inc. (TSHA)

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	* Price $	Shares After	Date	Ownership	Footnotes
transaction	TSHA	Common Stock	Purchase	$14.8M	+16.5M	$0.90	16.5M	Aug 16, 2023	See footnote	F1, F2
holding	TSHA	Common Stock					22K	Aug 16, 2023	See footnote	F3
holding	TSHA	Common Stock					2.09M	Aug 16, 2023	See footnote	F4
holding	TSHA	Common Stock					4.84M	Aug 16, 2023	See footnote	F1, F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Id	Content
F1	The change in the total shares held prior to the transactions reported herein reflects a change in form of ownership and, therefore, was not required to be reported pursuant to Section 16.
F2	The shares are held directly by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Revocable Trust"). The Reporting Person is the trustee of the Revocable Trust and has sole voting and investment power with respect to the shares held by the Revocable Trust.
F3	The shares are held directly by BKB G2 Investments, LLC ("BKB G2"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB G2, and has shared voting and investment power with respect to the shares held by BKB G2.
F4	The shares are held directly by BKB Growth Investments, LLC ("BKB"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB, and has shared voting and investment power with respect to the shares held by BKB.
F5	The shares are held directly by The PBM 2023 Grantor Retained Annuity Trust (the "Annuity Trust"). The Reporting Person is the trustee of the Annuity Trust and has sole voting and investment power with respect to the shares held by the Annuity Trust.