Mark C. McKenna - Jun 2, 2023 Form 4 Insider Report for Prometheus Biosciences, Inc. (RXDX)

Role: Chairman, President & CEO, Director
Signature: /s/ Timothy K. Andrews, attorney-in-fact for Mark C. McKenna
Stock symbol: RXDX
Transactions as of: Jun 2, 2023
Transactions value $: $355,336
Form type: 4
Date filed: 6/2/2023, 07:13 PM
Previous filing: Mar 17, 2023
Next filing: Jun 16, 2023

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	RXDX	Common Stock	Options Exercise	$355K	+123K	+222.2%	$2.90^*	178K	Jun 2, 2023	Direct	F1
transaction	RXDX	Common Stock	Options Exercise	$5.10	+3	+0%	$1.70^*	178K	Jun 2, 2023	Direct	F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	RXDX	Stock Option (Right to Buy)	Options Exercise	$0	-123K	-43.2%	$0.00	161K	Jun 2, 2023	Common Stock	123K	$2.90	Direct	F1, F3
transaction	RXDX	Stock Option (Right to Buy)	Options Exercise	$0	-3	0%	$0.00	133K	Jun 2, 2023	Common Stock	3	$1.70	Direct	F1, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This transaction represents an exercise and hold of stock options by the Reporting Person for tax planning purposes.
F2	Includes a total of 361 shares of the Issuer's common stock acquired pursuant to the Issuer's Employee Stock Purchase Plan.
F3	25% of the shares subject to the option vested and became exercisable on September 9, 2020, and 1/48th of the shares subject to the option vesting monthly thereafter, subject to the Report Person's continued service with the Issuer through each vest date.
F4	25% of the shares subject to the option vested and became exercisable on March 27, 2021, and 1/48th of the shares subject to the option vesting monthly thereafter, subject to the Report Person's continued service with the Issuer through each vest date.