DAVID ALTSHULER - 06 Feb 2023 Form 4 Insider Report for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Role: EVP, Global Research and CSO
Signature: /s/ Christiana Stevenson, Attorney-in-Fact
Issuer symbol: VRTX
Transactions as of: 06 Feb 2023
Net transactions value: -$154,483
Form type: 4
Filing time: 08 Feb 2023, 15:53:50 UTC
Previous filing: 03 Feb 2023
Next filing: 14 Feb 2023
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	VRTX	Common Stock	Options Exercise	$244,539	+1,304	+1.9%	$187.53	69,949	06 Feb 2023	Direct
transaction	VRTX	Common Stock	Sale	$3,605	-12	-0.02%	$300.39	69,937	06 Feb 2023	Direct	F1
transaction	VRTX	Common Stock	Sale	$21,140	-70	-0.1%	$302.00	69,867	06 Feb 2023	Direct	F1
transaction	VRTX	Common Stock	Sale	$30,364	-100	-0.14%	$303.64	69,767	06 Feb 2023	Direct	F1, F2, F3
transaction	VRTX	Common Stock	Sale	$106,473	-349	-0.5%	$305.08	69,418	06 Feb 2023	Direct	F1, F2, F4
transaction	VRTX	Common Stock	Sale	$190,154	-620	-0.89%	$306.70	68,798	06 Feb 2023	Direct	F1, F2, F5
transaction	VRTX	Common Stock	Sale	$47,286	-153	-0.22%	$309.06	68,645	06 Feb 2023	Direct	F1, F2, F6

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	VRTX	Stock Option (Right to Buy)	Options Exercise	$0	-1,304	-100%	$0.000000^*	0	06 Feb 2023	Common Stock	1,304	$187.53	Direct	F7

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.
F2	Dr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
F3	Open market sales reported on this line occurred at a weighted average price of $303.64 (range $303.37 to $304.27).
F4	Open market sales reported on this line occurred at a weighted average price of $305.08 (range $304.72 to $305.43).
F5	Open market sales reported on this line occurred at a weighted average price of $306.70 (range $306.32 to $307.25).
F6	Open market sales reported on this line occurred at a weighted average price of $309.06 (range $308.76 to $309.42).
F7	Fully vested.