D. Scott Coward - 14 Feb 2022 Form 4 Insider Report for EXACT SCIENCES CORP (EXAS)

Role: Chief Administrative Officer
Signature: /s/ D. Scott Coward by Mark R. Busch, attorney-in-fact
Issuer symbol: EXAS
Transactions as of: 14 Feb 2022
Net transactions value: +$188,137
Form type: 4
Filing time: 16 Feb 2022, 18:58:42 UTC
Next filing: 24 Feb 2022
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	EXAS	Common Stock	Award	$21,235	+328	+25%	$64.74	1,629	30 Apr 2021	Direct	F1
transaction	EXAS	Common Stock	Options Exercise	$311,127	+3,972	+244%	$78.33	5,601	14 Feb 2022	Direct	F2
transaction	EXAS	Common Stock	Sale	$144,224	-1,813	-32%	$79.55	3,788	15 Feb 2022	Direct	F3, F4
holding	EXAS	Common Stock						4,194	14 Feb 2022	Held in 401(k) Plan

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	EXAS	Restricted Stock Units	Options Exercise	$0	-3,972	-33%	$0.000000	7,944	14 Feb 2022	Common Stock	3,972		Direct	F5, F6

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents shares of common stock purchased through Employee Stock Purchase Plan.
F2	Represents shares of common stock received upon vesting of a restricted stock unit award.
F3	Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on February 14, 2022.
F4	In addition to the shares of Common Stock reported on this Form 4, which total 7,982 shares, Mr. Coward also holds, in the aggregate, an additional 56,322 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock.
F5	Each restricted stock unit represents a contingent right to receive one share of common stock.
F6	Represents a restricted stock unit award that partially vested on February 14, 2022. The restricted stock units vest in four equal annual installments beginning on February 14, 2021.