Jeffrey W. Sherman - 21 Sep 2021 Form 4 Insider Report for Horizon Therapeutics Public Ltd Co

Role: EVP and Chief Medical Officer
Signature: /s/ Miles W. McHugh, Attorney-in-Fact
Issuer symbol: N/A
Transactions as of: 21 Sep 2021
Net transactions value: -$4,737,688
Form type: 4
Filing time: 23 Sep 2021, 17:00:33 UTC
Previous filing: 30 Jul 2021
Next filing: 05 Oct 2021
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	HZNP	Ordinary Shares	Gift	$0	-4,042	-31%	$0.000000	9,115	03 Sep 2021	Direct
transaction	HZNP	Ordinary Shares	Gift	$0	+4,042	+18%	$0.000000	27,079	03 Sep 2021	See footnote	F1
transaction	HZNP	Ordinary Shares	Options Exercise	$352,122	+46,271	+508%	$7.61	55,386	21 Sep 2021	Direct
transaction	HZNP	Ordinary Shares	Sale	$5,089,810	-46,271	-84%	$110.00	9,115	21 Sep 2021	Direct	F2
holding	HZNP	Ordinary Shares						66,730	21 Sep 2021	By Spouse
holding	HZNP	Ordinary Shares						105,808	21 Sep 2021	See footnote	F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	HZNP	Stock Option (Right to Buy)	Options Exercise	$0	-46,271	-81%	$0.000000	10,729	21 Sep 2021	Ordinary Shares	46,271	$7.61	Direct	F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The shares are held in the Jeffrey W. Sherman Living Trust.
F2	The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 10, 2021.
F3	The shares are held in the name of the Jeffrey W. Sherman 2020 Gift Trust, of which the reporting person's spouse is the Trustee.
F4	The stock option is fully vested and exercisable.