James E. Flynn - 27 Feb 2026 Form 4 Insider Report for Larimar Therapeutics, Inc. (LRMR)

Role: Director, * Director by Deputization, 10%+ Owner
Signature: /s/ Jonathan Isler, Attorney-in-Fact
Issuer symbol: LRMR
Transactions as of: 27 Feb 2026
Net transactions value: +$25,000,000
Form type: 4
Filing time: 02 Mar 2026, 19:46:04 UTC
Previous filing: 24 Nov 2025
SEC: View on sec.gov

Reporting Owners (10)

Name	Relationship	Address	Signature	Signature date	CIK
Flynn James E	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001352546
DEERFIELD MANAGEMENT COMPANY, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001009258
Deerfield Mgmt III, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001610540
Deerfield Mgmt HIF, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001665736
Deerfield Mgmt IV, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001713467
Deerfield Mgmt L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001010823
Deerfield Private Design Fund III, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001603333
Deerfield Healthcare Innovations Fund, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001646981
Deerfield Private Design Fund IV, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001680307
DEERFIELD PARTNERS, L.P.	Director, * Director by Deputization, 10%+ Owner	345 PARK AVENUE SOUTH, 12TH FLOOR, NEW YORK	/s/ Jonathan Isler, Attorney-in-Fact	02 Mar 2026	0001301041

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	LRMR	Common Stock	Purchase	$5,420,050	+1,084,010	+11%	$5.00	10,622,928	27 Feb 2026	Through Deerfield Private Design Fund III, L.P.	F1, F2
transaction	LRMR	Common Stock	Purchase	$5,420,060	+1,084,012	+11%	$5.00	10,622,957	27 Feb 2026	Through Deerfield Private Design Fund IV, L.P.	F1, F2
transaction	LRMR	Common Stock	Purchase	$4,159,890	+831,978	+11%	$5.00	8,153,107	27 Feb 2026	Through Deerfield Healthcare Innovations Fund, L.P.	F1, F2
transaction	LRMR	Common Stock	Purchase	$10,000,000	+2,000,000	+48%	$5.00	6,207,982	27 Feb 2026	Through Deerfield Partners, L.P.	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. ("Fund III"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. ("Fund IV"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. ("Deerfield HIF"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. ("Deerfield Partners"). Deerfield Management Company, L.P. is the investment manager of Deerfield Partners, L.P., Fund III, Fund IV and Deerfield HIF (collectively, the "Funds"). James E. Flynn is the sole manager of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.
F2	In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

Content

This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. ("Fund III"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. ("Fund IV"). Deerfield Mgmt HIF, L.P. is the general partner of Deerfield Healthcare Innovations Fund, L.P. ("Deerfield HIF"). Deerfield Mgmt, L.P. is the general partner of Deerfield Partners, L.P. ("Deerfield Partners"). Deerfield Management Company, L.P. is the investment manager of Deerfield Partners, L.P., Fund III, Fund IV and Deerfield HIF (collectively, the "Funds"). James E. Flynn is the sole manager of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.

In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

Remarks:

Jonathan S. Leff, a partner in Deerfield Management, serves as a director of the Issuer. Jonathan Isler, Attorney-in-Fact: Power of Attorney, which is hereby incorporated by reference to Exhibit 24 to a Form 3 with regard to BiomX Inc. filed with the Securities and Exchange Commission on March 19, 2024 by Deerfield Private Design Fund V, L.P., Deerfield Healthcare Innovations Fund II, L.P., Deerfield Mgmt V, L.P., Deerfield Mgmt HIF II, L.P., Deerfield Management Company, L.P. and James E. Flynn.