Ian Alexander Webster - 18 Mar 2026 Form 3 Insider Report for NuCana plc (NCNA)

Role
Exhibit 24.1 - Power of Attorney Interim Chief Financial Officer
Signature
/s/ Ian Webster
Issuer symbol
NCNA
Transactions as of
18 Mar 2026
Net transactions value
$0
Form type
3
Filing time
18 Mar 2026, 17:39:28 UTC
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Webster Ian Alexander Exhibit 24.1 - Power of Attorney Interim Chief Financial Officer C/O NUCANA PLC, 3 LOCHSIDE WAY, EDINBURGH, UNITED KINGDOM /s/ Ian Webster 18 Mar 2026 0002117367

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
holding NCNA Options 18 Mar 2026 Ordinary Shares 49,625,635 Direct F1
holding NCNA Options 18 Mar 2026 Ordinary Shares 81,529,196 Direct F2
holding NCNA Options 18 Mar 2026 Ordinary Shares 12,874,360 Direct F3
holding NCNA Options 18 Mar 2026 Ordinary Shares 20,209,396 Direct F4
holding NCNA Options 18 Mar 2026 Ordinary Shares 54,352,798 Direct F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The ordinary shares, nominal value 0.0004 Pounds Sterling per share (the "Ordinary Shares"), of NuCana plc (the "Company") underlying this option have an exercise price of 0.004 Pounds Sterling, completed vesting on June 20, 2025 and expire June 20, 2035.
F2 The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling, completed vesting on January 14, 2026 and expire January 14, 2036.
F3 The Ordinary Shares underlying this option have an exercise price of 0.004 Pounds Sterling and will vest as to 25% on June 20, 2026, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service with the Company through the applicable vesting date.
F4 The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest as to 25% on June 20, 2026, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service with the Company through the applicable vesting date.
F5 The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest as to 25% on January 14, 2027, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service with the Company through the applicable vesting date.

Remarks:

Exhibit 24.1 - Power of Attorney Interim Chief Financial Officer