Cyrille Leperlier - 18 Mar 2026 Form 3 Insider Report for NuCana plc (NCNA)

Role
Director
Signature
/s/ Ian Webster, Attorney-in-Fact for Cyrille Leperlier
Issuer symbol
NCNA
Transactions as of
18 Mar 2026
Net transactions value
$0
Form type
3
Filing time
18 Mar 2026, 17:35:03 UTC
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Leperlier Cyrille Director C/O NUCANA PLC, 3 LOCHSIDE WAY, EDINBURGH, UNITED KINGDOM /s/ Ian Webster, Attorney-in-Fact for Cyrille Leperlier 18 Mar 2026 0002121554

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
holding NCNA Options 18 Mar 2026 Ordinary Shares 32,823,199 Direct F1
holding NCNA Options 18 Mar 2026 Ordinary Shares 32,823,199 Direct F2
holding NCNA Options 18 Mar 2026 Ordinary Shares 39,466,743 Direct F3
holding NCNA Options 18 Mar 2026 Ordinary Shares 39,466,743 Direct F4
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The ordinary shares, nominal value 0.0004 Pounds Sterling per share (the "Ordinary Shares"), of NuCana plc (the "Company") underlying this option have an exercise price of 0.004 Pounds Sterling, completed vesting on June 20, 2025 and expire June 20, 2035.
F2 The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest in full on June 20, 2026, subject to the Reporting Person's continued service with the Company through the applicable vesting date.
F3 The Ordinary Shares underlying this option have an exercise price of 0.0005 Pounds Sterling, completed vesting on January 14, 2026 and expire January 14, 2036.
F4 The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest in full on January 14, 2027, subject to the Reporting Person's continued service with the Company through the applicable vesting date.

Remarks:

Exhibit 24.1 - Power of Attorney