Theresa Margaret Ms Bruce - 18 Mar 2026 Form 3 Insider Report for NuCana plc (NCNA)

Role
Chief Operating Officer
Signature
/s/ Ian Webster, Attorney-in-Fact for Theresa Bruce
Issuer symbol
NCNA
Transactions as of
18 Mar 2026
Net transactions value
$0
Form type
3
Filing time
18 Mar 2026, 17:27:42 UTC
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Bruce Theresa Margaret Ms Chief Operating Officer C/O NUCANA PLC, 3 LOCHSIDE WAY, EDINBURGH, UNITED KINGDOM /s/ Ian Webster, Attorney-in-Fact for Theresa Bruce 18 Mar 2026 0002117971

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
holding NCNA Options 18 Mar 2026 Ordinary Shares 55,139,594 Direct F1
holding NCNA Options 18 Mar 2026 Ordinary Shares 55,139,594 Direct F2
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The ordinary shares, nominal value 0.0004 Pounds Sterling per share (the "Ordinary Shares"), of NuCana plc (the "Company") underlying this option have an exercise price of 0.004 Pounds Sterling, completed vesting on June 20, 2025 and expire June 20, 2035.
F2 The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest as to 25% on June 20, 2026, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service with the Company through the applicable vesting date.

Remarks:

Exhibit 24.1 - Power of Attorney