| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| MORTIMER IAN | PRESIDENT & CEO, Director | 3650 GILMORE WAY, BURNABY, BRITISH COLUMBIA, CANADA | /s/ Nathaniel Adams, Attorney-in-fact | 11 Mar 2026 | 0001619961 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | XENE | Common Shares | Options Exercise | +75,000 | +1250% | $8.40* | 81,000 | 09 Mar 2026 | Direct | ||
| transaction | XENE | Common Shares | Sale | $1,281,529 | -21,791 | -27% | $58.81 | 59,209 | 09 Mar 2026 | Direct | F1, F2 |
| transaction | XENE | Common Shares | Sale | $1,897,837 | -31,694 | -54% | $59.88 | 27,515 | 09 Mar 2026 | Direct | F1, F3 |
| transaction | XENE | Common Shares | Sale | $1,301,442 | -21,515 | -78% | $60.49 | 6,000 | 09 Mar 2026 | Direct | F1, F4 |
| transaction | XENE | Common Shares | Options Exercise | +25,000 | +417% | $3.10* | 31,000 | 09 Mar 2026 | Direct | ||
| transaction | XENE | Common Shares | Sale | $742,500 | -12,479 | -40% | $59.50 | 18,521 | 09 Mar 2026 | Direct | F1, F5 |
| transaction | XENE | Common Shares | Sale | $609,054 | -10,072 | -54% | $60.47 | 8,449 | 09 Mar 2026 | Direct | F1, F6 |
| transaction | XENE | Common Shares | Sale | $150,026 | -2,449 | -29% | $61.26 | 6,000 | 09 Mar 2026 | Direct | F1, F7 |
| transaction | XENE | Common Shares | Options Exercise | +105,000 | +1750% | $4.75* | 111,000 | 09 Mar 2026 | Direct | ||
| transaction | XENE | Common Shares | Sale | $2,568,802 | -43,348 | -37% | $59.26 | 72,652 | 09 Mar 2026 | Direct | F1, F8 |
| transaction | XENE | Common Shares | Sale | $3,704,052 | -61,652 | -91% | $60.08 | 6,000 | 09 Mar 2026 | Direct | F1, F9 |
| transaction | XENE | Common Shares | Options Exercise | +65,000 | +1083% | $9.44* | 71,000 | 09 Mar 2026 | Direct | ||
| transaction | XENE | Common Shares | Sale | $4,033,900 | -65,000 | -92% | $62.06 | 6,000 | 09 Mar 2026 | Direct | F1, F10 |
| transaction | XENE | Common Shares | Options Exercise | +20,000 | +333% | 26,000 | 09 Mar 2026 | Direct | F11 | ||
| transaction | XENE | Common Shares | Sale | $677,357 | -11,269 | -43% | $60.11 | 14,731 | 10 Mar 2026 | Direct | F12 |
| holding | XENE | Common Shares | 14,300 | 09 Mar 2026 | By Spouse |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | XENE | Stock Option | Options Exercise | -75,000 | -100% | $0.000000* | 0 | 09 Mar 2026 | Common Shares | 75,000 | $8.40 | Direct | F13 | |
| transaction | XENE | Stock Option | Options Exercise | -25,000 | -100% | $0.000000* | 0 | 09 Mar 2026 | Common Shares | 25,000 | $3.10 | Direct | F13 | |
| transaction | XENE | Stock Option | Options Exercise | -105,000 | -100% | $0.000000* | 0 | 09 Mar 2026 | Common Shares | 105,000 | $4.75 | Direct | F13 | |
| transaction | XENE | Stock Option | Options Exercise | -65,000 | -100% | $0.000000* | 0 | 09 Mar 2026 | Common Shares | 65,000 | $9.44 | Direct | F13 | |
| transaction | XENE | Performance Share Units | Award | +20,000 | $0.000000* | 20,000 | 09 Mar 2026 | Common Shares | 20,000 | Direct | F11 | |||
| transaction | XENE | Performance Share Units | Options Exercise | -20,000 | -100% | $0.000000* | 0 | 09 Mar 2026 | Common Shares | 20,000 | Direct | F11 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024. |
| F2 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $58.16 to $59.1425, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F3 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $59.16 to $60.15, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F4 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $60.16 to $61.00, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F5 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $59.03 to $60.02, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F6 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $60.05 to $61.035, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F7 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $61.055 to $61.555, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F8 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $58.745 to $59.735, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F9 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $59.75 to $60.60, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F10 | The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $62.00 to $62.30, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. |
| F11 | Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination. |
| F12 | The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading arrangement, in the form of a durable sell-to-cover instruction, adopted by the reporting person on December 3, 2025, solely to satisfy tax withholding obligations related to the vesting of PSUs granted on March 11, 2024. |
| F13 | The shares subject to this option are fully vested and exercisable. |