Jian Irish - 05 Dec 2025 Form 4 Insider Report for Metagenomi Therapeutics, Inc. (MGX)

Role: Chief Executive Officer, Director
Signature: /s/ Matthew L. Wein, attorney-in-fact
Issuer symbol: MGX
Transactions as of: 05 Dec 2025
Net transactions value: -$2,571
Form type: 4
Filing time: 09 Mar 2026, 17:15:57 UTC
Previous filing: 01 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Irish Jian	Chief Executive Officer, Director	C/O METAGENOMI THERAPEUTICS, INC., 5959 HORTON STREET, 7TH FLOOR, EMERYVILLE	/s/ Matthew L. Wein, attorney-in-fact	09 Mar 2026	0001995697

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	MGX	Common Stock	Gift		-228,462	-41%	$0.000000^*	335,377	05 Dec 2025	Direct	F1
transaction	MGX	Common Stock	Sale	$2,571	-1,607	-0.48%	$1.60	333,770	05 Mar 2026	Direct	F2
holding	MGX	Common Stock						292,714	05 Dec 2025	By Trust	F1, F3
holding	MGX	Common Stock						292,713	05 Dec 2025	By Trust	F1, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	On December 5, 2025, the Reporting Person transferred 114,231 and 114,231 shares of Issuer common stock to the Bruce Irish 2023 Irrevocable Trust FBO Jian Irish and Jian Irish 2023 Irrevocable Trust, respectively, for no consideration.
F2	These shares of common stock were automatically sold for the purpose of satisfying the Reporting Person's tax withholding obligations upon the vesting of certain restricted stock units granted to the Reporting Person on April 1, 2024, and does not represent a volitional trade by the Reporting Person.
F3	Shares held by the Bruce Irish 2023 Irrevocable Trust FBO Jian Irish. The Reporting Person disclaims beneficial ownership of these securities except to the extent of her pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.
F4	Shares held by the Jian Irish 2023 Irrevocable Trust. The Reporting Person disclaims beneficial ownership of these securities except to the extent of her pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.