| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| ORVILLE JACOB A | EVP, GM, Screening | C/O EXACT SCIENCES CORP., 5505 ENDEAVOR LANE, MADISON | /s/ Jacob A. Orville by Mark Busch, attorney-in-fact | 27 Feb 2026 | 0001263312 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| holding | EXAS | Common Stock | 100,403 | 25 Feb 2026 | Direct | F1 | |||||
| holding | EXAS | Common Stock | 1,759 | 25 Feb 2026 | Held in 401(k) Plan |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | EXAS | Restricted Stock Units | Award | $0 | +38,707 | $0.000000 | 38,707 | 25 Feb 2026 | Common Stock | 38,707 | Direct | F2, F3 |
| Id | Content |
|---|---|
| F1 | In addition to the shares of Common Stock reported on this Form 4, which total 102,162 shares, Mr. Orville also holds, in the aggregate, an additional 45,288 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. |
| F2 | Each restricted stock unit represents a contingent right to receive one share of common stock. |
| F3 | These restricted stock units vest in four equal annual installments beginning on February 25, 2027. |