| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Collard Craig A | Chief Executive Officer, Director | 100 REGENCY FOREST DRIVE, SUITE 300, CARY | /s/Kathryn Lester Attorney-in-fact for Craig Collard | 20 Jan 2026 | 0001363558 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Common Stock | Options Exercise | +13,797 | +2.6% | 536,921 | 19 Jan 2026 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Restricted Stock Units | Options Exercise | $0 | -13,797 | -11% | $0.000000 | 110,375 | 19 Jan 2026 | Common Stock | 13,797 | $0.000000 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | Each restricted stock unit represents a contingent right to receive one share of common stock. |
| F2 | The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (01/19/2024). |