Mark Hollywood - 09 Jan 2026 Form 3 Insider Report for Zymeworks Inc. (ZYME)

Role: EVP & Chief Operating Officer
Signature: /s/ Daniel Dex, Attorney-in-Fact
Issuer symbol: ZYME
Transactions as of: 09 Jan 2026
Net transactions value: $0
Form type: 3
Filing time: 13 Jan 2026, 17:04:03 UTC
Next filing: 13 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Hollywood Mark	EVP & Chief Operating Officer	C/O ZYMEWORKS INC., 108 PATRIOT DRIVE, SUITE A, MIDDLETOWN	/s/ Daniel Dex, Attorney-in-Fact	13 Jan 2026	0002104446

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	ZYME	Common Stock						121,367	09 Jan 2026	Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
holding	ZYME	Stock Option (Right to Buy)							09 Jan 2026	Common Stock	80,000	$15.23	Direct	F1, F2
holding	ZYME	Stock Option (Right to Buy)							09 Jan 2026	Common Stock	24,375	$35.20	Direct	F2, F3
holding	ZYME	Stock Option (Right to Buy)							09 Jan 2026	Common Stock	30,000	$34.82	Direct	F2, F4
holding	ZYME	Stock Option (Right to Buy)							09 Jan 2026	Common Stock	90,000	$7.00	Direct	F2, F5
holding	ZYME	Stock Option (Right to Buy)							09 Jan 2026	Common Stock	61,000	$8.00	Direct	F2, F6
holding	ZYME	Stock Option (Right to Buy)							09 Jan 2026	Common Stock	90,000	$10.56	Direct	F2, F7
holding	ZYME	Stock Option (Right to Buy)							09 Jan 2026	Common Stock	79,000	$13.22	Direct	F2, F8
holding	ZYME	Restricted Stock Unit							09 Jan 2026	Common Stock	20,000		Direct	F9, F10
holding	ZYME	Restricted Stock Unit							09 Jan 2026	Common Stock	53,000		Direct	F10, F11

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Stock option granted March 27, 2019.
F2	Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.
F3	Stock option granted March 10, 2020.
F4	Stock option granted March 10, 2021.
F5	Stock option granted March 10, 2022.
F6	Stock option granted January 5, 2023.
F7	Stock option granted January 5, 2024.
F8	Stock option granted January 10, 2025.
F9	60,000 restricted stock units ("RSUs") granted January 5, 2024; vest in three equal annual installments beginning January 5, 2025. As of January 9, 2026, 20,000 RSUs remain outstanding.
F10	Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.
F11	53,000 restricted stock units ("RSUs") granted January 10, 2025; vest in three equal annual installments beginning January 10, 2026. As of January 9, 2026, 53,000 RSUs remain outstanding.

Remarks:

Exhibit List - Exhibit 24 - Power of Attorney