| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Firestone Karen | Director | C/O AMYLYX PHARMACEUTICALS, INC., 55 CAMBRIDGE PARKWAY, SUITE 6W, CAMBRIDGE | /s/ Joshua B. Cohen, as Attorney in Fact | 23 Dec 2025 | 0001969821 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | AMLX | Common Stock | Purchase | $100,845 | +8,100 | +15% | $12.45 | 63,100 | 23 Dec 2025 | Direct |