| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Galbraith Kenneth | Chair & CEO, Director | C/O ZYMEWORKS INC., 108 PATRIOT DRIVE, SUITE A, MIDDLETOWN | /s/ Daniel Dex, Attorney-in-Fact | 22 Dec 2025 | 0001567045 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ZYME | Common Stock | Options Exercise | $0 | +100,000 | +124% | $0.000000 | 180,803 | 22 Dec 2025 | Direct | F1 |
| transaction | ZYME | Common Stock | Sale | $1,284,311 | -47,528 | -26% | $27.02 | 133,275 | 22 Dec 2025 | Direct | F2, F3 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ZYME | Restricted Stock Unit | Options Exercise | $0 | -100,000 | -100% | $0.000000 | 0 | 22 Dec 2025 | Common Stock | 100,000 | Direct | F4, F5 |
| Id | Content |
|---|---|
| F1 | Represents shares of common stock issued upon vesting of restricted stock units ("RSUs") granted on December 22, 2022. |
| F2 | Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees. |
| F3 | The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $26.83 to $27.16 inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. |
| F4 | Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. |
| F5 | The RSUS vested on December 22, 2025. |