John Nuss - 17 Dec 2025 Form 4 Insider Report for Ventyx Biosciences, Inc. (VTYX)

Role: CHIEF SCIENTIFIC OFFICER
Signature: /s/ Austin Rutherford, as Attorney-in-Fact
Issuer symbol: VTYX
Transactions as of: 17 Dec 2025
Net transactions value: -$97,840
Form type: 4
Filing time: 19 Dec 2025, 16:15:07 UTC
Previous filing: 03 Apr 2025
Next filing: 04 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Nuss John	CHIEF SCIENTIFIC OFFICER	C/O VENTYX BIOSCIENCES, INC., 12790 EL CAMINO REAL, SUITE 200, SAN DIEGO	/s/ Austin Rutherford, as Attorney-in-Fact	19 Dec 2025	0001874108

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	VTYX	Common Stock	Options Exercise	$0	+34,930	+7.5%	$0.000000	502,156	17 Dec 2025	Direct	F1
transaction	VTYX	Common Stock	Sale	$97,840	-12,675	-2.5%	$7.72	489,481	18 Dec 2025	Direct	F2, F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	VTYX	Restricted Stock Units	Options Exercise	$0	-34,930	-100%	$0.000000	0	17 Dec 2025	Common Stock	34,930		Direct	F1, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each restricted stock unit ("RSU") represents a contingent right to receive one share of Ventyx Biosciences, Inc. common stock.
F2	Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units.
F3	Represents the weighted average share price of an aggregate total of 12,675 shares sold in the price range of $7.595 to $7.85. The reporting owner undertakes to provide upon request by the Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
F4	Subject to the reporting person's continuing to be a Service Provider (as defined in the 2021 Equity Incentive Plan) through such applicable vesting date, twenty five percent (25%) of the RSUs subject to the award shall vest on the one (1) year anniversary of the Vesting Commencement Date, and twenty five percent (25%) of the RSUs subject to the award shall vest on each of the next three Vesting Commencement Date anniversaries thereafter. "Vesting Commencement Date" shall mean December 17, 2021.