Harith Rajagopalan - Dec 4, 2025 Form 4 Insider Report for FRACTYL HEALTH, INC. (GUTS)

Role: Chief Executive Officer, Director
Signature: /s/ Lisa A. Davidson, Attorney-in-fact
Stock symbol: GUTS
Transactions as of: Dec 4, 2025
Transactions value $: $19,999
Form type: 4
Date filed: 12/8/2025, 07:05 AM
Previous filing: Mar 3, 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Rajagopalan Harith	Chief Executive Officer, Director	3 VAN DE GRAAFF DRIVE, SUITE 200, BURLINGTON	/s/ Lisa A. Davidson, Attorney-in-fact	2025-12-08	0001667672

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GUTS	Common Stock	Purchase	$20K	+10.4K	+2.12%	$1.92	502K	Dec 4, 2025	Direct	F1
holding	GUTS	Common Stock						292K	Dec 4, 2025	By 2021 Irrevocable Trust
holding	GUTS	Common Stock						292K	Dec 4, 2025	By 2016 Irrevocable Trust
holding	GUTS	Common Stock						18.6K	Dec 4, 2025	By 2021 Family Trust

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The shares of Common Stock were purchased by the Reporting Person from the Issuer in a private placement, which transaction is exempt from Section 16(b) in accordance with Rule 16b-3(d)(1) promulgated under the Securities Exchange Act of 1934, as amended.