Herriot Tabuteau - Dec 2, 2025 Form 4 Insider Report for Axsome Therapeutics, Inc. (AXSM)

Role
Chief Executive Officer, Director, 10%+ Owner
Signature
/s/ Nick Pizzie, Attorney-in-Fact
Stock symbol
AXSM
Transactions as of
Dec 2, 2025
Transactions value $
-$11,007,199
Form type
4
Date filed
12/4/2025, 07:39 PM
Previous filing
Nov 5, 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
TABUTEAU HERRIOT Chief Executive Officer, Director, 10%+ Owner C/O AXSOME THERAPEUTICS, INC., ONE WORLD TRADE CENTER, 29TH FLOOR, NEW YORK /s/ Nick Pizzie, Attorney-in-Fact 2025-12-04 0001219927

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction AXSM Common Stock Options Exercise $395K +49.3K +681.31% $8.02 56.5K Dec 2, 2025 Direct F1, F2
transaction AXSM Common Stock Sale -$7.12M -49.3K -87.2% $144.59 7.23K Dec 2, 2025 Direct F2, F3, F4
transaction AXSM Common Stock Options Exercise $162K +20.2K +278.92% $8.02 27.4K Dec 3, 2025 Direct F1, F2
transaction AXSM Common Stock Sale -$2.96M -20.2K -73.61% $146.94 7.23K Dec 3, 2025 Direct F2, F3, F5
transaction AXSM Common Stock Options Exercise $84.7K +10.6K +146.05% $8.02 17.8K Dec 4, 2025 Direct F1, F2
transaction AXSM Common Stock Sale -$1.56M -10.6K -59.36% $148.18 7.23K Dec 4, 2025 Direct F2, F3, F6
holding AXSM Common Stock 7.34M Dec 2, 2025 See Footnote F7

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction AXSM Stock Option (Right to Buy) Options Exercise $0 -49.3K -19.56% $0.00 203K Dec 2, 2025 Common Stock 49.3K $144.59 Direct F1, F2
transaction AXSM Stock Option (Right to Buy) Options Exercise $0 -20.2K -9.95% $0.00 182K Dec 3, 2025 Common Stock 20.2K $146.94 Direct F1, F2
transaction AXSM Stock Option (Right to Buy) Options Exercise $0 -10.6K -5.79% $0.00 172K Dec 4, 2025 Common Stock 10.6K $148.18 Direct F1, F2
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Necessary exercise of stock options set to expire due to attainment of the 10-year expiration date of such options.
F2 Such transaction was pursuant to a pre-approved 10b5-1 plan.
F3 Represents the subsequent sale of the underlying shares of the aforementioned exercise of stock options.
F4 Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $141.79 and $149.23.
F5 Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $142.66 and $148.39.
F6 Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $146.77 and $149.41.
F7 Such shares are held by an entity, of which the reporting person has voting and dispositive power, and therefore, the reporting person is deemed to be the indirect beneficial owner of such shares.