Bhavesh Ashar - 01 Dec 2025 Form 4 Insider Report for Tyra Biosciences, Inc. (TYRA)

Role: Chief Operating Officer
Signature: /s/ Ali D. Fawaz, Attorney-in-Fact
Issuer symbol: TYRA
Transactions as of: 01 Dec 2025
Net transactions value: $0
Form type: 4
Filing time: 01 Dec 2025, 18:17:34 UTC
Previous filing: 02 Jul 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Ashar Bhavesh	Chief Operating Officer	C/O TYRA BIOSCIENCES, INC., 2656 STATE STREET, CARLSBAD	/s/ Ali D. Fawaz, Attorney-in-Fact	01 Dec 2025	0001849740

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	TYRA	Stock Option (Right to Buy)	Award	$0	+300,000		$0.000000	300,000	01 Dec 2025	Common Stock	300,000	$20.81	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	25% of the shares subject to the option shall vest on December 1, 2026, and 1/48th of the total number of shares subject to the option vest monthly thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date.