| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Cusack Thomas | Director | 100 REGENCY FOREST DRIVE, SUITE 300, CARY | /s/ Kathryn Lester Attorney-in-fact for Thomas P. Cusack | 12 Nov 2025 | 0002094824 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Common Stock | Award | +37,879 | 37,879 | 08 Nov 2025 | Direct | F1, F2 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Stock Option (Right to Buy) | Award | $249,999 | +227,272 | $1.10 | 227,272 | 08 Nov 2025 | Common Stock | 227,272 | $1.10 | Direct | F3 |
| Id | Content |
|---|---|
| F1 | The shares were granted as restricted stock units which vest in 16 equal quarterly installments beginning one quarter after the date of grant. |
| F2 | Each restricted stock unit represents a contingent right to receive one share of common stock. |
| F3 | The stock options vest and become exercisable in 48 equal monthly installments beginning one month after the date of grant. |