| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Forbes William P | EVP, Chief Development Officer | 100 REGENCY FOREST DRIVE, SUITE 300, CARY | /s/ Kathryn Lester Attorney-in-Fact for William P. Forbes | 21 Oct 2025 | 0001314760 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Common Stock | Options Exercise | +3,874 | +2.6% | 154,509 | 19 Oct 2025 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HRTX | Restricted Stock Units | Options Exercise | $0 | -3,874 | -10% | $0.000000 | 34,869 | 19 Oct 2025 | Common Stock | 3,874 | $0.000000 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | Each restricted stock unit represents a contingent right to receive one share of common stock. |
| F2 | The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (01/19/2024). |