Mark L. Jacobson - 16 Sep 2025 Form 4 Insider Report for Axsome Therapeutics, Inc. (AXSM)

Signature
/s/ Mark Jacobson
Issuer symbol
AXSM
Transactions as of
16 Sep 2025
Net transactions value
-$5,044,627
Form type
4
Filing time
17 Sep 2025, 19:00:04 UTC
Previous filing
10 Jun 2025
Next filing
22 Sep 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Jacobson Mark L. Chief Operating Officer C/O AXSOME THERAPEUTICS, INC., ONE WORLD TRADE CENTER, 29TH FLOOR, NEW YORK /s/ Mark Jacobson 17 Sep 2025 0001805812

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction AXSM Common Stock Sale $671,927 -5,783 -100% $116.19 0 16 Sep 2025 Direct F1, F2, F5
transaction AXSM Common Stock Options Exercise $123,750 +25,000 $4.95 25,000 16 Sep 2025 Direct F2, F3
transaction AXSM Common Stock Options Exercise $72,750 +15,000 +60% $4.85 40,000 16 Sep 2025 Direct F2, F3
transaction AXSM Common Stock Sale $4,569,200 -40,000 -100% $114.23 0 16 Sep 2025 Direct F2, F4, F6

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction AXSM Stock Option (Right to Buy) Options Exercise $0 -25,000 -100% $0.000000 0 16 Sep 2025 Common Stock 25,000 $4.95 Direct F2, F3
transaction AXSM Stock Option (Right to Buy) Options Exercise $0 -15,000 -100% $0.000000 0 16 Sep 2025 Common Stock 15,000 $4.85 Direct F2, F3
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Represents the sale of underlying shares of previously exercised stock options.
F2 Such transaction was pursuant to a pre-approved 10b5-1 plan.
F3 Necessary exercise of stock options set to expire due to attainment of the 10-year expiration date of such options.
F4 Represents the subsequent sale of the underlying shares of the aforementioned exercise of stock options.
F5 Represents the sale price of all shares in an open market transaction.
F6 Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $112.93 and $116.87.