L. Becker Hewes - 15 Sep 2021 Form 4 Insider Report for Blueprint Medicines Corp (BPMC)

Role: Chief Medical Officer
Signature: /s/ Ariel Hurley, Attorney-in-Fact
Issuer symbol: BPMC
Transactions as of: 15 Sep 2021
Net transactions value: -$617,539
Form type: 4
Filing time: 17 Sep 2021, 16:19:39 UTC
Previous filing: 17 Sep 2021
Next filing: 19 Oct 2021
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	BPMC	Common Stock	Options Exercise	$579,600	+8,750	+30%	$66.24	38,020	15 Sep 2021	Direct	F1
transaction	BPMC	Common Stock	Sale	$421,949	-4,140	-11%	$101.92	33,880	15 Sep 2021	Direct	F1, F2
transaction	BPMC	Common Stock	Sale	$581,889	-5,759	-17%	$101.04	28,121	15 Sep 2021	Direct	F1, F3
transaction	BPMC	Common Stock	Sale	$173,487	-1,734	-6.2%	$100.05	26,387	15 Sep 2021	Direct	F1, F4
transaction	BPMC	Common Stock	Sale	$19,814	-200	-0.76%	$99.07	26,187	15 Sep 2021	Direct	F1, F5

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	BPMC	Stock Option (Right to Buy)	Options Exercise	$0	-8,750	-25%	$0.000000	26,250	15 Sep 2021	Common Stock	8,750	$66.24	Direct	F1, F6

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Effected pursuant to a trading plan adopted on August 13, 2021 pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.
F2	The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $101.45 to $102.44 per share. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (5) in this form 4.
F3	The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.49 to $101.40 per share.
F4	The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.60 to $100.32 per share.
F5	The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $98.92 to $99.20 per share.
F6	This option was granted on June 1, 2020. This option vested with respect to 1/48th of the shares underlying the option on June 1, 2021 and as to an additional 1/48th of the shares underlying the option each month thereafter.