David E. I. Pyott - 01 Jun 2026 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Reporting relationship: Director
Issuer ticker: ALNY
Reported as of: 01 Jun 2026
Net transaction value: -$1,145,853
SEC form: 4
Accepted by SEC: 03 Jun 2026, 16:25:20 UTC
Prior SEC filing: 22 May 2026
Source filing: View source filing
Reporting owner signature: Brett Budzinski, Attorney-in-Fact For: David E.I. Pyott

Key filing fact

David E. I. Pyott filed Form 4 for ALNYLAM PHARMACEUTICALS, INC. (ALNY) on 03 Jun 2026.

Key facts

This page summarizes David E. I. Pyott's Form 4 filing for ALNYLAM PHARMACEUTICALS, INC. (ALNY).
7 reported transactions and 1 derivative row are listed below.
Accepted by SEC: 03 Jun 2026, 16:25.

Change

Previous filing in this sequence was filed on 22 May 2026.
Current net transaction value: -$1,145,853.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001051578 Primary reporting owner

PYOTT DAVID E I

Relationship: Director
Address: 675 WEST KENDALL STREET, CAMBRIDGE
Signature: Brett Budzinski, Attorney-in-Fact For: David E.I. Pyott
Signature date: 03 Jun 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

ALNY transaction

Common Stock

Options Exercise

Transaction value
Shares: +3,830
Change %: +242%
Price: $0.000000^*
Shares after: 5,412
Date: 01 Jun 2026
Ownership: Direct
Footnotes: F1

ALNY transaction

Common Stock

Sale

Transaction value: $274,191
Shares: -921
Change %: -17%
Price: $297.71
Shares after: 4,491
Date: 01 Jun 2026
Ownership: Direct
Footnotes: F1, F2

ALNY transaction

Common Stock

Sale

Transaction value: $351,219
Shares: -1,175
Change %: -26%
Price: $298.91
Shares after: 3,316
Date: 01 Jun 2026
Ownership: Direct
Footnotes: F1, F3

ALNY transaction

Common Stock

Sale

Transaction value: $366,441
Shares: -1,222
Change %: -37%
Price: $299.87
Shares after: 2,094
Date: 01 Jun 2026
Ownership: Direct
Footnotes: F1, F4

ALNY transaction

Common Stock

Sale

Transaction value: $148,856
Shares: -495
Change %: -24%
Price: $300.72
Shares after: 1,599
Date: 01 Jun 2026
Ownership: Direct
Footnotes: F1, F5

ALNY transaction

Common Stock

Sale

Transaction value: $5,145
Shares: -17
Change %: -1.1%
Price: $302.65
Shares after: 1,582
Date: 01 Jun 2026
Ownership: Direct
Footnotes: F1

ALNY holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 27,900
Date: 01 Jun 2026
Ownership: by Trust
Footnotes: F6

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

ALNY transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value
Shares: -3,830
Change %: -100%
Price: $0.000000^*
Shares after: 0
Date: 01 Jun 2026
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 3,830
Exercise price: $70.20
Footnotes: F1, F7

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 7 footnotes

Footnote F1

The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

Footnote F2

The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $297.31 to $297.99. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

Footnote F3

The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $298.33 to $299.33. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

Footnote F4

The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $299.36 to $300.19. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

Footnote F5

The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $300.45 to $301.15. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

Footnote F6

The shares of ALNY common stock were purchased by the David E I Pyott Trust, of which the reporting person is trustee.

Footnote F7

This stock option was fully vested and exercisable as of June 3, 2017.