Ruoyu Chen - 07 Jan 2026 Form 4 Insider Report for GYRE THERAPEUTICS, INC. (GYRE)

Role: Chief Financial Officer
Signature: /s/ Ruoyu Chen
Issuer symbol: GYRE
Transactions as of: 07 Jan 2026
Net transactions value: $0
Form type: 4
Filing time: 09 Jan 2026, 16:01:14 UTC
Previous filing: 16 Aug 2024
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Chen Ruoyu	Chief Financial Officer	C/O GYRE THERAPEUTICS, INC., 12770 HIGH BLUFF DRIVE, SUITE 150, SAN DIEGO	/s/ Ruoyu Chen	09 Jan 2026	0001982080

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	GYRE	Stock Option (Right to Buy)	Award	$0	+50,000		$0.000000	50,000	07 Jan 2026	Common Stock	50,000	$7.31	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This option represents a right to purchase a total of 50,000 shares of the Issuer's common stock, 25% of which will vest on January 7, 2027, with the remaining vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date.