Ping Zhang - 05 Aug 2025 Form 4 Insider Report for GYRE THERAPEUTICS, INC. (GYRE)

Role: Director
Signature: /s/ Ruoyu Chen, as attorney-in-fact for Ping Zhang
Issuer symbol: GYRE
Transactions as of: 05 Aug 2025
Net transactions value: $0
Form type: 4
Filing time: 07 Aug 2025, 20:00:41 UTC
Previous filing: 28 May 2025
Next filing: 09 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Zhang Ping	Director	C/O GYRE THERAPEUTICS, INC., 12770 HIGH BLUFF DRIVE, SUITE 150, SAN DIEGO	/s/ Ruoyu Chen, as attorney-in-fact for Ping Zhang	07 Aug 2025	0002050176

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	GYRE	Stock Option (Right to Buy)	Award	$0	+250,000		$0.000000	250,000	05 Aug 2025	Common Stock	250,000	$6.92	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This option represents a right to purchase a total of 250,000 shares of the Issuer's common stock, 25% of which will vest on August 5, 2026, with the remaining vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date.