Weiguo Ye - 01 Apr 2025 Form 4 Insider Report for GYRE THERAPEUTICS, INC. (GYRE)

Role: Chief Operating Officer
Signature: /s/ Ruoyu Chen, as attorney-in-fact for Weiguo Ye
Issuer symbol: GYRE
Transactions as of: 01 Apr 2025
Net transactions value: +$37,500
Form type: 4
Filing time: 14 May 2025, 20:21:22 UTC
Previous filing: 25 Apr 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Ye Weiguo	Chief Operating Officer	C/O GYRE THERAPEUTICS, INC., 12770 HIGH BLUFF DRIVE, SUITE 250, SAN DIEGO	/s/ Ruoyu Chen, as attorney-in-fact for Weiguo Ye	14 May 2025	0001985496

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GYRE	Common Stock	Options Exercise	$37,500	+50,000	+7.7%	$0.7500	700,000	01 Apr 2025	Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	GYRE	Stock Option (Right to Buy)	Options Exercise	$0	-50,000	-4.9%	$0.000000	965,115	01 Apr 2025	Common Stock	50,000	$0.7500	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	These options are vested in full.