Yann Mazabraud - 02 Mar 2026 Form 4 Insider Report for RHYTHM PHARMACEUTICALS, INC. (RYTM)

Role: EVP, Head of International
Signature: /s/ Stephen Vander Stoep, attorney-in-fact for Yann Mazabraud
Issuer symbol: RYTM
Transactions as of: 02 Mar 2026
Net transactions value: $0
Form type: 4
Filing time: 04 Mar 2026, 20:22:48 UTC
Previous filing: 18 Feb 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Mazabraud Yann	EVP, Head of International	222 BERKELEY STREET, 12TH FLOOR, BOSTON	/s/ Stephen Vander Stoep, attorney-in-fact for Yann Mazabraud	04 Mar 2026	0001774702

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	RYTM	Stock Options (Right to Buy)	Award		+35,000		$0.000000^*	35,000	02 Mar 2026	Common Stock	35,000	$94.94	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The stock options were granted on March 2, 2026. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.