Hunter C. Smith - 02 Mar 2026 Form 4 Insider Report for RHYTHM PHARMACEUTICALS, INC. (RYTM)

Role: Chief Financial Officer
Signature: /s/ Stephen Vander Stoep, attorney-in-fact for Hunter C. Smith
Issuer symbol: RYTM
Transactions as of: 02 Mar 2026
Net transactions value: +$41,473
Form type: 4
Filing time: 02 Mar 2026, 20:56:40 UTC
Previous filing: 19 Feb 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Smith Hunter C	Chief Financial Officer	C/O RHYTHM PHARMACEUTICALS, INC., 222 BERKELEY STREET, 12TH FLOOR, BOSTON	/s/ Stephen Vander Stoep, attorney-in-fact for Hunter C. Smith	02 Mar 2026	0001636385

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	RYTM	Common Stock	Options Exercise	$41,473	+6,099	+5.5%	$6.80	116,611	02 Mar 2026	Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	RYTM	Stock Options (Right to Buy)	Options Exercise	$0	-6,099	-6.3%	$0.000000	91,401	02 Mar 2026	Common Stock	6,099	$6.80	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The options are fully vested.