Ramkumar Mandalam - 10 Dec 2025 Form 4 Insider Report for Cryoport, Inc. (CYRX)

Role: Director
Signature: /s/ Ramkumar Mandalam
Issuer symbol: CYRX
Transactions as of: 10 Dec 2025
Net transactions value: -$115,540
Form type: 4
Filing time: 12 Dec 2025, 17:30:13 UTC
Previous filing: 24 Jul 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Mandalam Ramkumar	Director	C/O CRYOPORT INC., 112 WESTWOOD PLACE, SUITE 350, BRENTWOOD	/s/ Ramkumar Mandalam	12 Dec 2025	0001611439

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CYRX	Common Stock	Sale	$115,540	-11,570	-13%	$9.99	80,758	10 Dec 2025	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.93 to $10.0696, inclusive.

Remarks:

With respect to prices reported as weighted average prices in Table I, the reporting person undertakes to provide to Cryoport, Inc., any security holder of Cryoport, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in the applicable footnotes to this Form 4.