Alex Nemiroff - 20 Nov 2025 Form 4 Insider Report for Praxis Precision Medicines, Inc. (PRAX)

Role
General Counsel and Secretary
Signature
/s/ Alex Nemiroff
Issuer symbol
PRAX
Transactions as of
20 Nov 2025
Net transactions value
-$2,998,725
Form type
4
Filing time
21 Nov 2025, 21:41:39 UTC
Previous filing
14 Feb 2025
Next filing
09 Jan 2026
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Nemiroff Alex General Counsel and Secretary C/O PRAXIS PRECISION MEDICINES, INC., 99 HIGH STREET, 30TH FLOOR, BOSTON /s/ Alex Nemiroff 21 Nov 2025 0001827760

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction PRAX Common Stock Options Exercise $143,719 +1,714 +8.2% $83.85 22,546 20 Nov 2025 Direct
transaction PRAX Common Stock Options Exercise $832,640 +6,230 +28% $133.65 28,776 20 Nov 2025 Direct
transaction PRAX Common Stock Options Exercise $108,070 +2,434 +8.5% $44.40 31,210 20 Nov 2025 Direct
transaction PRAX Common Stock Options Exercise $250,949 +5,652 +18% $44.40 36,862 20 Nov 2025 Direct
transaction PRAX Common Stock Options Exercise $518,154 +9,100 +25% $56.94 45,962 20 Nov 2025 Direct
transaction PRAX Common Stock Sale $327,139 -1,714 -3.7% $190.86 44,248 20 Nov 2025 Direct F1
transaction PRAX Common Stock Sale $2,568,198 -13,339 -30% $192.53 30,909 20 Nov 2025 Direct F2
transaction PRAX Common Stock Sale $188,789 -977 -3.2% $193.23 29,932 20 Nov 2025 Direct F3
transaction PRAX Common Stock Sale $1,768,130 -9,100 -30% $194.30 20,832 20 Nov 2025 Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction PRAX Stock Option (Right to Buy) Options Exercise $0 -1,714 -100% $0.000000 0 20 Nov 2025 Common Stock 1,714 $83.85 Direct F4
transaction PRAX Stock Option (Right to Buy) Options Exercise $0 -6,230 -100% $0.000000 0 20 Nov 2025 Common Stock 6,230 $133.65 Direct F5
transaction PRAX Stock Option (Right to Buy) Options Exercise $0 -2,434 -100% $0.000000 0 20 Nov 2025 Common Stock 2,434 $44.40 Direct
transaction PRAX Stock Option (Right to Buy) Options Exercise $0 -5,652 -71% $0.000000 2,347 20 Nov 2025 Common Stock 5,652 $44.40 Direct F6
transaction PRAX Stock Option (Right to Buy) Options Exercise $0 -9,100 -32% $0.000000 19,717 20 Nov 2025 Common Stock 9,100 $56.94 Direct F7
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $190.720 to $191.540. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.
F2 The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $192.003 to $193.000. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.
F3 The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $193.010 to $193.960. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.
F4 This option was fully vested as of January 1, 2024.
F5 This option was fully vested as of September 9, 2024.
F6 The shares underlying this stock option vested as to 25% on January 12, 2024 and the remaining shares vest in substantially equal monthly installments over the following 36 months, subject to the Reporting Person's continued service through each vesting date.
F7 The shares underlying this stock option vested as to 7/48ths on July 29, 2024 and the remaining shares vest in substantially equal monthly installments over the following 41 months, subject to the Reporting Person's continued service through each vesting date.

Remarks:

The transactions reported in this Form 4 were effected for estate planning purposes.