| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Maccecchini Maria-Luisa | President & CEO, Director | C/O ANNOVIS BIO, INC., 101 LINDENWOOD DR, SUITE 225, MALVERN | /s/ Maria Maccecchini | 12 Nov 2025 | 0001315018 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ANVS | Common Stock | Purchase | $200,000 | +97,561 | +8.8% | $2.05 | 1,212,020 | 28 Oct 2025 | Direct |